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In multiple sclerosis (MS) patients, treatment with rituximab (chimeric anti-CD20 mAb) generated an unwanted immune response in up to 37% of patients (73)

Cytometry 14(5):492-6, 1993
Furthermore, APOE4-targeted replacement mice, carrying the human APOE4 allele (a known strong risk factor for developing late-onset AD), display significant depressive-like behaviors compared to APOE3 counterparts, especially under stress conditions (Fang et al., 2021
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