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An alternative approach that has been explored experimentally in the porcine ischemic injury model to limit formation of LA inhibitory fragments while maintaining the ability of LA to induce recovery of barrier function involves addition of small doses of LA over time and suggest that 0.1 M LA applied every 45 min is effective (49)

The majority of the published literature examines each compound independently, and the synergy hypothesis, while mechanistically well-supported, has not yet been the subject of large-scale controlled studies

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