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FIGURE 1 2.2 GSHs role in brain-resident immune cells In the CNS, GSH protects mitochondrial function, prevents lipid peroxidation, and maintains the redox state of cysteine residues in proteins

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Nrf2 is a central transcription factor that activates cellular antioxidant genes via the Keap1Nrf2ARE signalling pathway ( Nrf2 , which restricts antioxidant gene transcription by sequestering Nrf2 in the cytoplasm and promoting its degradation ( Nrf2 , thereby enhancing endogenous antioxidant defences