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People with MTHFR mutation have an increased risk of developing mental health issues, fatigue, cardiovascular problems, migraines, certain types of cancer, and neural tube defects in fetuses

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Increased serum thyroid stimulating hormone (TSH) levels have been hypothesized as a participating factor for endometriosis development and progression

Cyanocobalamin, by contrast, requires enzymatic conversion in the liver and tissues to become active
