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This senolytic approach, addressing DNA damage-induced senescence, offers a promising strategy for eradicating residual disease and improving cancer treatment outcomes

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Later studies demonstrated that blocking the local release of norepinephrine inhibits cutaneous vasoconstriction during cold stress without affecting cutaneous vasodilation during heat stress (243) and that presynaptic blockade of cholinergic nerves results in an absence of active cutaneous vasodilation during heat stress (244)