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Among these three experimental treatments, the total cholesterol content in shrimp fed with a diet of krill oil was significantly higher than those in the soybean lecithin and egg yolk lecithin experimental groups ( p 1, p 1, p 0.05, Figures 11AC)

These mechanisms lead to the prolonged activation of trigeminal neurons, astrocytes, and microglia around meningeal blood vessels, inflammatory cascades within brain parenchyma reaching the glia limitans, and the dispersal of arachidonic acid (AA) and potassium ions into the perivascular area (9, 10, 39)

Animal models Four-week-old male athymic mice were purchased from the Shulaibao Biotechnology (Wuhan, China), and reared in the Animal Center of Renmin Hospital of Wuhan University

The resulting three-dimensional human intestinal organoids (HIOs) consisted of a polarized, columnar epithelium that was patterned into villus-like structures and crypt-like proliferative zones that expressed intestinal stem cell markers (Spence et al., 2011)
