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Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes

Hcy can promote oxidative stress by facilitating the production of ROS, thereby initiating vascular inflammation (Figure 4)

Despite some controversies, such as drug concentration and timing, inconsistent conclusions due to different definitional parameters, and insufficient research on the mechanism of influence, these findings can help clinicians choose the most appropriate treatment plan and clinical follow-up

At the molecular level, X-linked immune genes such as Tlr7 escape inactivation in females, promoting stronger antiviral responses, whereas age-related mosaic loss of the Y chromosome in males impairs leukocyte gene regulation