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Abstract Contrast-induced nephropathy (CIN) remains a significant clinical challenge, particularly following the administration of iodinated agents such as urographin

[DOI] [PubMed] [Google Scholar] [24].Kuhajda FP

As a result, a mild increase in ROS has the potential to reduce the self-renewal capacity of HSCs by triggering HSC senescence, which can result in premature exhaustion of HSCs and LT-BM injury, which can result in permanent thrombocytopenia [72,73,74]

Future studies on the dose response in canines to supplemented l-carnitine may be necessary, as the effects seem to vary dependent on animal variables