glutathione peroxidase extraction Modeling the Catalytic Cycle of by Nuclear Magnetic Resonance Spectroscopic Analysis of Selenocysteine Selenenic Acids The Selenoprotein Glutathione Peroxidase 4:

Description

Mechanistically, FSP1 reduces CoQ and vitamin K, generating radical-trapping antioxidants (RTAs) that effectively terminate lipid peroxidation chain reactions at the plasma membrane, thereby guarding against ferroptosis

Abbreviations 2-AG: 2-Arachidonoylglycerol ABCA1: ATP-binding cassette transporter A1 ACAT: Acyl coenzyme A-cholesterol acyltransferase ACC: Acetyl-CoA carboxylase ACLY: ATP-citrate lyase ACSS: Acetyl-CoA synthetase AD: Alzheimers disease ADPN: Adiponectin AIE: Aggregation-induced emission Akt: Also known as protein kinase B, PKB AMPK: Adenosine monophosphate-activated protein kinase ATGL: Adipose triglyceride lipase Aur: Auranofin AVA: Avasimibe AS: Atherosclerosis CD36: Cluster of differentiation 36 CDCA: Controlled-release chenodeoxycholic acid-loaded COD: Cholesterol oxidase CRC: Colorectal cancer CS: Chondroitin sulfate CS-BR: Chondroitin sulfate-bilirubin CtBP2: C-terminal binding protein 2 CuS NPs: CuS nanoparticles CPT: Carnitine palmitoyl transferase CVDs: Cardiovascular diseases CRISPR: Clustered regularly interspaced short palindromic repeats Cas9: CRISPR-associated protein 9 DCs: Dendritic cells DNL: De novo lipogenesis DGAT: Diacylglycerol acyltransferase DHHC: Asp-His-His-Cys EMT: Epithelial-mesenchymal transition ER: Endoplasmic reticulum FABPs: Fatty acid-binding proteins FAO: Fatty acid -oxidation FAs: Fatty acids FASN: Fatty acid synthase FATPs: Fatty acid transport proteins FFAs: Free fatty acids FSP1: Ferroptosis suppressor protein 1 FU: Fucoidan FX: Fucoxanthin GPX4: Glutathione peroxidase 4 GSH: Glutathione GOs: Graphene oxide HDL-C: High-density lipoprotein-cholesterol HMG-CoA: 3-Hydroxy-3-methylglutaryl-CoA HMGCR: 3-Hydroxy-3-methylglutaryl (HMG)-CoA reductase HSL: Hormone-sensitive lipase HSCs: Hepatic stellate cells HIROZ: HSA-IR820@OA@ZIF-8 ICD: Immunogenic cell death IPP: Isopentenyl pyrophosphate IRTM: Immunosuppressive residual tumor microenvironment LCAD: Long-chain acyl-CoA dehydrogenase LCF: Licofelone LCFAs: Long-chain fatty acids LDs: Lipid droplets LDL-C: Low-density lipoprotein-cholesterol LDLR: Low-density lipoprotein receptor LSECs: Liver sinusoidal endothelial cells LPO: Lipid peroxidation LXR: Liver X receptors mTOR: Mammalian target of rapamycin MUFA: Monounsaturated fatty acids MONDs: Molybdenum oxide nanodots MGLL: Monoglyceride lipase MYC: Myelocytomatosis virus oncogene cellular homolog MCAD: Medium-chain acyl-CoA dehydrogenase M1: Pro-inflammatory phenotype M2: Anti-inflammatory (M2) phenotype NADPH: Nicotinamide adenine dinucleotide phosphate hydrogen NAFLD: Nonalcoholic fatty liver disease NIR-II: Near-infrared-II NPs: Nanoparticles NPC1L1: Niemann-Pick type C1-like 1 Nrf2: Nuclear factor erythroid 2-related factor 2 OA: Osteoarthritis OMs: Outer membranes PA: Palmitic acid PCBP: Pd/hCeO 2 -BMS309403@platelet membrane PCSK9: Proprotein convertase subtilisin/kexin type 9 PD: Parkinsons disease pDox: Doxorubicin prodrug PDT: Photodynamic therapy P-G3: Polycation-based nanomedicine polyamidoamine generation 3 PI3K: Phosphoinositide 3-kinase PLIN: Perilipins Plu: PluriSin PMeTPP-MBT: 3,6-bis(4-methylthiophen-2-yl)-2,5-bis(2-octyldodecyl) pyrrolo[3,4-c]pyrrole- 1,4(2H,5H)-dione (PMeTPP) and 3,3-dimethoxy-2,2-bithiophene (MBT) PPa: Phosphorbide A PPARs: Peroxisome proliferator-activated receptors PUFAs: Polyunsaturated fatty acids RA: Rumenic acid RBCM: Red blood cell membrane Rec-tNVs: Reconstructed turmeric-derived nanovesicles ROS: Reactive oxygen species RSL3: Ras-selective lethal 3 SCAP: SREBP cleavage-activating protein SCD: Stearoyl-CoA desaturase SERAC1: Serine active site containing 1 SFAs: Saturated fatty acids SIB: Silybin SIM: Simvastatin siRNA: Small interfering RNA SQLE: Squalene epoxidase SREBP: Sterol regulatory element-binding protein STAT: Signal transducer and activator of transcription TADCs: Tumor-associated dendritic cells TAK1: Transforming growth factor--activated kinase 1 TAMs: Tumor-associated macrophages TCA: Tricarboxylic acid TG: Triglycerides TME: Tumor microenvironment TNBC: Triple-negative breast cancer TOFA: 5-(Tetradecyloxy)-2-furoic acid Treg: Regulatory T cell UCP1: Uncoupling protein 1 USP22: Deubiquitinating enzyme ubiquitin-specific protease 22 ZIF-8: Zeolitic imidazolate framework-8 References Harayama T, Riezman H