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Notably, melatonin plays a dual role: it acts as an immunostimulant in basal or immunosuppressed states, enhancing defenses against infections and tumors, while serving as an anti-inflammatory agent during excessive immune activation, such as in septic shock [18,19,20] (Figure 3)

Several factors, including cytokines, proteases, growth factors, gut microbiota, and dietary components are known to regulate intestinal TJs opening ( Intestinal epithelial cells and mononuclear phagocytes sense bacteria or their products mainly through pattern recognition receptors such as TLRs (166)

LT inhibits CYP11A1/CYP17A1-mediated androgen synthesis and promotes CYP19A1-dependent aromatization by targeting ovarian steroidogenic enzymes