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The physical integrity of this barrier relies heavily on protein structures known as tight junctions (including proteins like occludin, claudins, and zonula occludens-1 or ZO-1)

[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Dorsey E.R., Sherer T., Okun M.S., Bloem B.R

Nrf2/HO-1 signaling activation alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis

The survival and quality of life of these patients and of the older person can be improved by counteracting loss of muscle mass and strength, and different approaches to this have been explored, including nutritional supplementation, resistance training and anabolic drugs
