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Indeed, a mass difference of 32 Da between unmodified and S -sulfinylated proteins in a standard proteomics workflow has been used to detect S -sulfinic acid by MS ( S -O 2 H)
However, a growing body of evidence reveals a pronounced immunoinflammatory phenotype in OA, wherein macrophages, T/B lymphocytes, and inflammatory factors such as IL-1, TNF-, and IL-6 play a critical role in the local microenvironment (105)
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