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NADPH, one product of the G6PD reaction, is a potent quasicompetitive inhibitor, and because most of the coenzyme in cells is in the reduced form, it can be assumed that G6PD is normally under strong inhibition

In addition, higher drug concentration was also noticeable in the brain areas
Furthermore, thyroid hormones activate the renin-angiotensin-aldosterone system which results in an increased blood volume due to an increase in fluid reabsorption

Clark et al., 2024)
