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In-depth investigation into the tissue-specific functions of these parallel pathways in chondrocytes and their crosstalk with the main GPX4 pathway holds significant translational medical importance for developing novel OA treatment strategies (Figure 1)

The following primary antibodies were obtained from Cell Signaling Technology and used at a dilution of 1:1000: anti-Thioredoxin 1 (C63C6) (#2429), anti-TXNIP (D5F3E) (#14715), anti-Thioredoxin reductase 1 (TXNRD1) (#15140) and anti-GAPDH (14C10) (#2118)

The architecture of the Rag GTPase signaling network

By targeting specific DNA methylation changes, personalized therapeutic approaches for PD may become a reality (206)