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doi: 10.1001/jama.2012.5669 107 RicciE.RonchettiS.GabrielliE.PericoliniE.GentiliM.RosellettiE.et al

Upon activation, Nrf2 translocates to the nucleus and binds to antioxidant response elements (AREs) in promoter regions, inducing transcription of antioxidant genes [41]

Zinc plays a role in the activity of enzymes like glutathione reductase , which converts the used-up oxidized form back into the active, reduced form

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