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Especially, the production of reactive nitrogen species (RNS), which are nitric oxide (NO)-derived oxidants, has been involved in the pathogenesis of these neurodegenerative diseases [72,73,74]
Furthermore, NADPH is required for several cellular biochemical reactions such as the synthesis of fatty acids and triacylglycerol, nucleotides as well as amino acids (ONeill et al., 2016
6A-D, Extended Data Fig
