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However, additional data was gathered with the knockout mice that indicated that while AOD9604 did not lead to significant weight loss or increase in lipolysis without the beta(3)-adrenergic receptors, there was an increase in energy expenditure and fat oxidation

This injection is commonly prescribed to treat or prevent vitamin B12 deficiency, which can occur due to factors such as poor dietary intake, malabsorption issues, or certain medical conditions

It is also added to many fortified foods

In the foundational mouse study, MOTS-c prevented diet-induced obesity and reversed insulin resistance without changes in food intake or exercise (Lee et al