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Under conditions of repeated TCR engagement without co-stimulation starting at day 2, histidine-treated naive CD8 + T cells showed significantly increased cumulative fold expansion over time, indicating preserved proliferative capacity and resistance to exhaustion-associated dysfunction (Extended Data Fig

Nat Rev Microbiol (2021) 19:51427

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Meredith IT, Currie KE, Anderson TJ, Roddy MA, Ganz P, Creager MA: Postischemic vasodilation in human forearm is dependent on endothelium-derived nitric oxide