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Description
The urine metabolic profile was used to identify the panel of urine metabolomics signature of hyperinsulinemia and insulin resistance in PCOS [111]
Catabolism: ,-Unsaturated aldehydes such as 4-hydroxy- trans -2-nonenal can be oxidized to non-toxic carboxylic acids by aldehyde dehydrogenases (ALDH), of which three classes coded by 18 genes have been identified in human tissues, before the products are further oxidized by the introduction of a 9hydroxyl group for elimination as a conjugate in urine
Related research materials include the sibling melanocortin peptides Melanotan 2 and PT-141
Analogs targeting arginase and arginine deiminase, the enzymes involved in arginine depletion, have been developed
