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In early tumor stages, M1 macrophages exert anti-tumor effects through pro-inflammatory cytokine production, such as TNF- and IL-1, and antigen presentation, yet their functions are often compromised by immunosuppressive mechanisms within the TME

[80,92] assessed the efficacy and effects of baicalin in human cells from patients with UC (N=33 divided into active and inactive groups) and compare it with irritable bowel syndrome and healthy subjects

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Clinical Diagnosis Thalassemia major: in children under two years of age, severe microcytic anemia, mild jaundice, and hepatosplenomegaly Thalassemia intermedia: in older children with similar clinical pictures