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doi: 10.1161/ATVBAHA.111.241893

Last updated on Jan 19, 2026

These include new or worsening acne and excessive hair growth, unexplained weight changes, persistent fatigue, nipple discharge when not breastfeeding, severe pelvic pain, headaches or vision changes, hot flashes outside of the typical perimenopausal age, and difficulty conceiving

The theory is that gradual dose reduction gives the body time to recalibrate appetite and metabolic signaling, rather than experiencing a sudden return to pre-treatment hunger levels
