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Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo
doi:10.1080/10715760701625075

The potential utility of incorporating this mechanism into complex LCR/beta-globin LVs was suggested by our discovery that unwanted RNA splicing is the key determinant of LCR/beta-globin -RV instability and low titers, and that this problem could be largely corrected by the removal of undesirable splice sites [131]
S1), suggests that this enzyme is highly conserved
