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[Manuscript submitted for publication] Mller T, Johann L, Jannack B et al (2011) Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-napthoquinones a new strategy to combat malarial parasites

Francis AM, Sepesi B, Correa AM, Blum MA, Erasmus JJ, Lee JH, Maru DM, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Welsh JW, Swisher SG , Hofstetter WL

Such discrimination in cell killing may lead to reduction in on-target off-tumour toxicity in healthy tissue displaying lower levels of the target antigen, leading to an increased therapeutic window similar to affinity tuning explored for CAR-T cells 37

Over time, this can contribute to a range of symptoms including fatigue, weight gain, mood imbalances, hormonal disruption, and increased susceptibility to illness making cortisol balance a cornerstone of long-term health and resilience