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Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease

Microparticles can be formulated into diverse dosage forms such as dry powders, injectable suspensions (e.g., microspheres and liposomes), and are suitable for multiple routes of administration, including oral, pulmonary, and parenteral delivery, as summarized in Table 1B

One caveat that should also be noted is that many animal models involve relatively severe challenge conditions for example, direct cerebral injection of virus and so the extrapolation of any conclusions to natural exposure of humans should be treated with caution

551,552 Clinical progress and challenges At present, there are more and more clinical trials regarding mitochondria-targeted therapies, covering different disease directions, especially diseases related to mitochondrial dysfunction, such as cancers, motor muscle diseases, neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and rare mitochondrial diseases
