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[DOI] [PubMed] [Google Scholar] 219.Rafii S

The nuclear factor erythroid 2-related factor 2 (Nrf2) is well-known due to its capability in improving antioxidant defense system via targeting down-stream mediators including heme oxygenease-1 (HO-1), superoxide dismutase (SOD) and NADPH quinone reductase 1 (NQO1) (Song et al., 2020)

Genistein mitigates diet-induced obesity and metabolic dysfunctions in gonadectomized mice with some sex-differential effects

However, even for vitamin D, not all studies offer concordant results ( Similarly, some randomized studies suggest a potential benefit in the administration of melatonin at variable doses (3 to 6 mg/day) with a significant reduction in SCORAD in both cases ( However, the role of the age and the efficacy of combination approaches have to be further assessed