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Relationship of cytosolic glutathione to efflux and mitochondrial sequestration

Collectively, these results directly demonstrate that resistance-causing PfK13 mutations in early rings result in a 1.5-fold loss in PfK13 protein abundance, which decreases intra-parasitic heme levels and subsequently impairs peroxide antimalarial activation

[Google Scholar] 86.Nakashima A., Yamada K., Iwata O., Sugimoto R., Atsuji K., Ogawa T., Ishibashi-Ohgo N., Suzuki K

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