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p62 binds to p53 and inhibits its ubiquitination (Wang et al., 2018)
Similar content being viewed by others Introduction Reactive oxygen species (ROS) are expected products of oxidative metabolism, and must be tightly regulated in the normal brain
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In addition to decreasing GSH, OTA inhibition of Nrf2 expression will decrease the production of the GST isoform GSTP1, which facilitates the detoxification of the lipid peroxidation product 4-hydoxynonenal (4-HNE) by facilitating the conjugation of 4-HNE with GSH
