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In early studies, selective knockout of the GPX4 gene in hippocampal neurons promotes neurodegeneration and cell death in a non-apoptotic manner, which provide preliminary evidence for GPX4 as a particular regulator of ferroptosis (Seiler et al., 2008)

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4.3 Iron (Fe) Iron is a crucial component of hemoglobin and myoglobin and participates in various physiological processes in organisms, especially in DNA synthesis, red blood cell production, oxygen transport, energy metabolism, and enzyme activity

recently showed that Mn exposure reduces the phosphorylation of the transcription factor SOX2, decreasing the expression of the RNA demethylase FTO, which facilitates the mA-dependent degradation of GRIN1 and GRIN3B transcripts, thus revealing that the SOX2FTOGRIN axis is a novel mechanistic target 174