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Nevertheless, challenges associated with BMP-2 include its short half-life, complex production equipment and preparation process, as well as supraphysiological doses, which may lead to side effects such as inflammation, pain, heterotopic ossification, or even osteolysis [403]
[12] DSIP abundance has been observed to be lower in cerebrospinal fluid of research models of depression compared to the same controls
doi:10.1177/03635465251357593 Vasireddi N, Hahamyan H, Salata MJ, et al
In the case of oral supplementation, there appears to be no difference between taking it sublingually or swallowing it
