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Finally, the design of long-term trials with clinically meaningful endpoints encounters logistical challenges, as demonstrated by the premature termination of numerous phase III studies due to insufficient enrollment or delayed therapeutic effects

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The current experimental data indicate glucocorticoids have direct effects on the endothelium, and depending on the context these effects may be beneficial (e.g., infection) or detrimental (e.g., hypertension associated with chronically elevated levels of glucocorticoids)