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In some embodiments, high viscosity formulations or devices contain from about 15% to about 21% of a viscosity enhancing agent or viscosity modulating agent (e.g., gelling components such as polyoxyethylene-polyoxypropylene copolymers)

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7.5 Improving OSC bioavailability: delivery system design One of the major practical barriers to clinical translation of many OSCs is their poor bioavailabilitydue to instability (e.g., rapid degradation of thiosulfinates), poor aqueous solubility, susceptibility to first-pass metabolism, and limited systemic exposure