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Three biosynthetic pathways regulate the cellular NAD + level: (1) the de novo synthesis pathway, (2) the PreissHandler pathway, and (3) the salvage pathway [15]
Vascular effects include the enhanced production of several vasoconstrictors from endothelial and mesangial cells, such as endothelin-1, platelet-activating factor, and arachidonic acid metabolites, mainly prostaglandins and thromboxane [ 45 , 50 ]

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