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It is important to recognize that while the disease affects the SN neurons and cause the classical symptoms, other brain regions, such as respiratory nuclei, also undergo degeneration

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emerging evidence strongly suggests that curcumin enhances mitochondrial biogenesis and protects against mitochondrial dysfunction, thereby boosting cellular energy production and directly combating peripheral and central fatigue (Zhang H et al., 2024)

Following that, RIPK1 interacts with RIPK3 via their RIP homotypic interaction motifs (RHIMs), driving the assembly of the high-molecular-weight amyloid-like necrosome (16)