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Studies suggest that by displacing FOXO4, the peptide releases p53 to translocate to the cytoplasm and mitochondria, where it activates Bax/Bak pore formation and caspase-mediated apoptosis

As water soluble vitamins they need to be taken in on a daily basis and they are equally rapidly excreted so B COMPLEX VITAMINS must be supplemented on a regular basis

Such peptides minimally affect healthy tissues, reducing the risk of side effects

* Correspondence: Youjun Mi, [email protected] Tan, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers