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Second, the MGBA is bidirectional and the gut highly modulates, as much as the brain influences, state of gut physiology
Bhabak, G

and (3) patients with overt hypothyroidism or autoimmune thyroiditis (e.g., Hashimotos disease), for whom a KD may be either beneficial or destabilizing depending on diet quality, energy balance, and adherence to repletion protocols
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This explanation can also be a convictive evidence to support our result that selenium had advantage in preventing the incidence of Keshan disease