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Description
The D-Nle-Trp-Ile-NH-(CH 2 )5- CONH 2 analog had intermediate inhibitory activity, and the D-Nle-Met-Ile-NH-(CH 2 )5- CONH 2 analog showed no ability to effect on Met activation

EE was determined using the ultrafiltration-centrifugation technique

Vomiting rates with cagrilintide monotherapy were significantly lower than with GLP-1 receptor agonists
Intranasal administration is quick and painless
