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Description
Melatonin levels are highest at night and lowest during the day
In animal models, the heightened pathway activity is closely associated with radiotoxicity, and the attenuation of TGF-/Smad signaling reduces fibrosis
The effects are felt within hours, not weeks, and we can administer much higher, more therapeutic doses than what can be tolerated orally
Llodra JC, Rodriguez A, Ferrer B, Menardia V, Ramos T, Morato M
