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Les scientifiques du Luxembourg Institute of Health (LIH) dcryptent ici, chez la souris, ce mcanisme molculaire qui favorise l'activation du systme immunitaire humain : les lymphocytes T, ces globules blancs du systme immunitaire luttent efficacement contre les agents pathognes la condition que le gne Gclc soit correctement exprim dans la cellule

[DOI] [PMC free article] [PubMed] [Google Scholar] 254.Botchkarev V, Botchkareva N, Albers K, Chen L, Welker P, Paus R

These observations demonstrate that GSH and GSH-rich YE offer a defense against liver damage in ethanol-induced oxidative stress, primarily by enhancing the expression of antioxidant enzymes via the activation of the Nrf2/Keap1 signaling pathway

In addition, CB-839 has been extensively studied in hematological malignancies such as acute myeloid leukemia (AML) (Gregory et al., 2019), myelodysplastic syndrome (MDS) (Okabe et al., 2022), and multiple myeloma (MM) ( TABLE 2 Clinical trials on targeting glutamine metabolism