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Consistent with this, Sahnoun et al

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[DOI] [PubMed] [Google Scholar] 86.Reddy G.B., Bhat K.S

In schizophrenia (SZ), Down Syndrome, and bipolar disorder (BD), increased brain insulin resistance and reduced IGF-1 signaling drive allostatic load/overload, leading to physiological dysregulation and the presentation of more severe symptoms throughout the body [44,45,46]
