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It had advanced into clinical trials as an anti-atherosclerotic agent, although it failed in a phase III trial (Muldrew and Franks, 2009)

243 Uricase Uricase, facilitating enhanced uric acid excretion involves the administration of exogenous urate oxidase, is an enzyme which not endogenously expressed in humans

10.1161/01.STR.29.1.12 298 YamamotoS.HagiwaraS.HidakaS.ShinguC.GotoK.KashimaK.et al (2011)
Therefore, inadequate zinc levels could not stimulate insulin receptor tyrosine kinase in patients with PCOS