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Attenuation of the IGF-1/AKT pathway in muscle satellite cells from CKD mice leads to reduced levels of myogenic markers, resulting in poor muscle regeneration, fibrosis, and the consequent muscle wasting.134 In hemodialysis patients, it has been recently demonstrated that the association between plasma IGF-1 and muscle strength is comparable to that of the myostatin, a well-known inhibitor of muscle growth, and both similarly predict mortality in this population.135 In this regard, the relationship between higher plasma IGF-1, muscle strength and survival could be expected

13 Cyanosis is not specific for methemoglobinemia

Cell Metabolism, 27 (3), 513-528

Schmidt M, Butterweck V