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The peptide increased FSH and LH concentrations when baseline levels were suppressed, while decreasing concentrations when initially elevated [8]

In the LPS-induced acute lung injury mouse model, treatment of GHK-Cu also significantly suppressed TNF- and IL-6 expression with a significant decrease of both NF-B p65 and p38 MAPK signaling, suggesting that GHK-Cu is useful for the development of novel anti-inflammatory therapies [22]

It has been proposed that this peptide may directly affect metabolism and reduce associated complications independent of its effects on obesity

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