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It has been CMS's policy since then to include hospitals with state-to-state MGCRB reclassifications to a nearby state's rural area along with hospitals reclassified under section 1886(d)(8)(E) of the Act in this regulatory hold harmless policy

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It reduces the expression of chemokines MCP-1 and RANTES, which are essential for TAM recruitment, and further suppresses TAM activation by decreasing M2 macrophage markers and tumor-promoting factors like MMP-2, MMP-9, and VEGF