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MSH is used as a cofactor for MSH-dependent enzymes during detoxification of toxins, electrophiles and antibiotics in Actinomycetes (Figure 9, Table 1)

There are different forms of B12, with methylcobalamin and cyanocobalamin being the most common

Cells were seeded in complete medium consisting of RPMI-1640 supplemented with 10% FCS (Sigma), 1% Penicillin/Streptomycin (GIBCO), 1% L-Glutamine (Sigma), and 55 mM -mercaptoethanol (GIBCO)
Hyaluronic Acid: Work as a moisture-binding agent to support skin hydration by helping retain moisture, improving smoothness and suppleness
