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These properties include: Aqueous solubility (which affects dissolution) Stability in the acidic environment of the stomach and enzymatic environment of the intestine, Molecular size , and pKa (which determines its ionization state and ability to cross lipid membranes) 12 Dosage Form and Formulation: The design of the drug product can significantly impact bioavailability
[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Saikrishnan K., Yeeles J.T., Gilhooly N.S., Krajewski W.W., Dillingham M.S., Wigley D.B
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