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It usually appears on sun-exposed areas of the body, particularly the face, head, or neck

En casos de hipotiroidismo, este mecanismo es especialmente relevante, ya que las clulas suelen no interpretar correctamente las seales hormonales, lo que ralentiza el metabolismo y provoca una cada en los niveles de energa

However, these agents are not widely available and further studies are needed to strengthen their incorporation into clinical practice (42)

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