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Description
A complex process observed in invasive solid tumours of epithelial origin in which the cancer cells acquire a mesenchymal phenotype, break through the basement membrane and enter the bloodstream or lymphatic system by the process of intravasation
None of that exists today
It directly stimulates the proliferation, survival, and invasion of tumor cells, and induces production of pro-angiogenic cytokines that promote tumorigenesis in both immune and non-immune cells in the tumor microenvironment
By evening, the acute stimulatory effect has diminished
