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In complex I, the main site of electron leakage to oxygen appear to be the iron-sulphur clusters and in complex III it appears to be the Q 1o semiquinone (277)
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For example, superoxide dismutases (SODs), which detoxify superoxide anion radicals, can be classified as CuZnSOD, MnSOD, or FeSOD, based on the metal cofactor
This reduces the burden on any single person and ensures the person with ME/CFS has more consistent support
