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Additional information Edited by G Melino Supplemental Information accompanies the paper on the Cell Death Discovery website ( Supplementary information Rights and permissions This work is licensed under a Creative Commons Attribution 4.0 International License

14) are glycoside hydrolases that cleave the -1,4 glycosidic linkages of chitin

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The etiology of ALS remains largely elusive in the majority of cases, with fewer than 10% attributed to specific genetic mutations involving genes such as SOD1, C9orf72, TDP43, and FUS (78)