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Research indicates that abnormal activation of the HGF/c-MET pathway may influence the growth and activity of immune-suppressing cells in the TME, impacting the multiplication and activation of T and NK cells
The induction of neuroprotective genes, such as Bcl-2 and Bcl-xl, also contributes to HGF inhibition of apoptosis (Tsuzuki et al., 2000, 2001
